ASIP2 |
ASK2 |
primary oocytes |
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[apoptosis signal regulating kinase 1] Mitogen-activated protein kinases (abbr. MAPK) regulate a wide variety of cellular responses in a signaling cascade that involves a variety of different kinases for which highly conserved homologous proteins exist in yeast, Drosophila melanogaster, and mammalian cells. ASK1 has been shown to complement a yeast mutant lacking the functional yeast homolog (Ichijo et al, 1997).
ASK1 (170 kDa) (Ichijo et al, 1997) is a is a ubiquitously expressed member of the MAPK kinase kinase (MAP3K) protein family. The cDNA has been isolated from a human
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