Asporin |
ASPP-1 |
motheaten |
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[Apoptosis stimulating Protein for p53] ASPP is a protein family (ASPP-1 [Apoptosis stimulating Protein for p53-1], ASPP-2 [Apoptosis stimulating Protein for p53-2]) interacting with p53. The approved gene symbol for ASPP-1 is PPP1R13B [protein phosphatase 1 regulatory subunit 13B].
ASPP specifically enhances p53 induced apoptosis but not cell cycle arrest. Expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Inhibition of ASPP functions has been shown to suppress the apoptotic function of endogenous p53 in response to
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