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Aminoacyl-tRNA synthetases

[Aminoacyl-tRNA synthetase]

Aminoacyl tRNA-synthetases (also simply tRNA synthetases) are ubiquitously expressed and play an essential role in protein synthesis in all cell types by charging tRNAs with the cognate amino acid, producing aminoacyl-tRNAs that read codons to translate messenger RNAs into proteins (Carter, 1993 Ibba and Söll, 2000). Most aminoacyl-tRNA synthetases can also produce dinucleotide polyphosphates in a variety of physiological conditions, which can function as second messengers both extra- and intra-cellularly (for overview see Tshori et al, 2014).

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