Angiopoietin Y |
Angiostatin |
Noelin-3 |
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This peptide with the sequence PEVYIHPF (Pro-Glu-Val-Tyr-Ile-His-Pro-Phe) has been identified by Jankowski et al (2011) who point out that the peptide differs from angiotensin-2 in Pro¹ and Glu² instead of Asp¹ and Arg² and suggest that angioprotectin may be generated enzymatically from angiotensin-2. Angioprotectin antagonizes the contractile actions of angiotensin-2 on rat aortic rings.
The physiological antagonism of vasoconstrictor actions of angiotensin-2 by angioprotectin is mediated by the Mas receptor. Angioprotectin has a stronger affinity to the Mas receptor than Angiotensin-(1-7). Plasma
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