aureins |
AU-rich elements |
mouse Developmental Kinase-1 |
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This peptide of 40 amino acids (AACSDRAHGHICESFKSFCKDSGRNGVKLRANCKKTCGLC) has been purified from the mesoglea of a scyphoid jellyfish Aurelia aurita (Ovchinnikova et al, 2006). The peptide contains six cysteines forming three disulfide bonds. Aurelin has no structural homology with other identified antimicrobial peptides but reveals partial similarity with defensins and K+ channel-blocking toxins of sea anemones. Aurelin is active against Gram-positive bacteria and Gram-negative bacteria.
For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also: Innate immunity and defense peptides Dictionary.
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