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BAR

[Bifunctional Apoptosis Regulator] This protein is anchored in the intracellular membrane. It has been identified as an apoptosis regulator by virtue of its ability to inhibit cell death induced by BAX (Zhang et al, 2000). The approved gene symbol is BFAR. The protein is known also as RNF47 [RING finger protein 47].

The BAR protein contains a SAM domain, which is required for its interactions with BCL2 and BCLxL and for suppression of BAX induced cell death. The inhibitor is functional in mammalian cells and yeast. BAR also contains a domain ... ... ... ... ... Subscribe to continue reading! ... ...

 

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