BFL-1

A human member of the BCL2 protein family that has been isolated from a human fetal liver. BFL-1 (175 amino acids) is a homolog murine A1 (72 % amino acid identity); abbr. and approved gene symbol BCL2A1 [BCL2-related protein A1] (see also: A1). The gene has been identified independently as GRS. Another designation for this gene is BCL2-like-5 (BCL2L5).

BFL-1 is expressed abundantly in the bone marrow and at a low level in some other tissues. The protein has been found to be overexpressed in certain human epithelial and hematopoietic malignancies with expression preferentially detected in infiltrating ... ... ... ...
 
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Entry last modified: March 2012