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A1 is a member of the BCL2 protein family involved in counteracting apoptosis. Murine A1 is a homolog of human BFL-1 (Lin et al, 1993). Another designation for this gene is BCL2-like-5 (BCL2L5) or BCL2A1 (BCL2-related protein A1). The gene has been identified independently as GRS.
A1 has been identified as a hematopoietic-specific, early inducible gene (see also: hematopoiesis, early response gene). Stable transfection of A1 into 32D cells retards apoptosis caused by growth factor
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