BaF3

An immortalized murine bone marrow-derived pro-B-cell line with a pre-B-cell phenotype (Palacios and Steinmetz, 1985). Growth and proliferation of these cells depend on the presence of IL3 (Palacios et al, 1984) (see also: Factor-dependent cell lines, BMC). When cultured in the presence of IL3, or other growth-promoting factors, BaF3 cells are highly resistant to X-irradiation and the cytotoxic drugs etoposide and cisplatin (Collins et al, 1992). BaF3 cells undergo cell death by apoptosis upon factor withdrawal. In the absence of IL3, cell death ... ... ... ...
 
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Entry last modified: May 2014