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high mobility group protein-1
for COPE Fund
abbr. BCT. Called also B-cell tropin or B-cell trophin in some publications)
This factor was identified originally in the pituitary pars intermedia and subsequently in plasma of genetically obese (ob/ob) mice (Billingham et al, 1982) and genetically obese Zucker rats (fa/fa) (Morton et al, 1991). The factor is found also in human plasma (Salvatoni et al, 1986).
Beta-cell trophin acts as an insulin secretagogue and potentiates glucose induced insulin secretion (Beloff-Chain et al, 1980). Beloff-Chain et al (1983) have reported that the factor is related to corticotropin-like intermediate lobe peptide (CLIP), the 18-39 fragment of ACTH and that Beta-cell trophin is identical with the octadecapeptide ACTH[22-39].
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ENTRY LAST MODIFIED: November 2004
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