Coco

(after the Spanish word meaning head) This protein, identified originally as a cDNA clone termed 51-B6, is a member of a protein family that includes Cerberus, Gremlin and DAN, all of which are secreted inhibitors of BMP (Bell et al, 2003).

Coco expression is induced by SMAD7. Coco is expressed maternally in an animal to vegetal gradient, and its expression levels decline rapidly following gastrulation. The protein is expressed broadly in the ectoderm until the end of gastrulation. Coco is a secreted protein and one of its function may be to block BMP and TGF-beta signals in the ectoderm ... ... ... ...
 
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