GREM3 |
Gremlin-1 |
Oxi-c |
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This secreted factor, called also gremlin-1 (approved gene symbol: GREM1), was isolated by using a Xenopus laevis expression cloning screen (Hsu et al, 1998). Gremlin belongs to a gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN. Another designation is CKTSF1B1 (see: CKTSF [cysteine knot superfamily]). A previously used gene designation is DAND2 [DAN domain family member 2]. McMahon et al (2000) have reported that human Gremlin is identical with IHG-2 [increased in high clucose-2], a
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