DETELQD |
Deubiquitinase DESI2 |
VQRWLIVWRIRKamide |
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Deterin, encoded by gene CG12265, is a Drosophila melanogaster protein that belongs to the family of apoptosis inhibitors. The protein resembles Survivin in that it possesses a single baculovirus inhibitor of apoptosis BIR domain and no RING finger motif (see: IAP). Deterin prevents apoptotic cell death induced by the caspase-dependent apoptosis activator reaper or by cytotoxidants. Jiang et al (2001) have reported that HeLa cell apoptosis induced by survivin antisense oligonucleotides can be partially complemented by Deterin. A chimeric protein consisting of the Deterin
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