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This term has multiple meanings:
(-1-) endothelial derived growth factor
This biochemically uncharacterized factor is found in the conditioned medium of human umbilical vein endothelial cells. The factor stimulates the proliferation of fibroblasts and induces quiescent fibroblasts to proliferate (Bianchi-Scarra et al, 1985).
EDGF also promotes the proliferation of both normal and pathological progenitors of bone marrow fibroblasts (CFU-F) by increasing both the number and the size of the colonies (see also: Colony formation assay).
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(-2-) eye-derived growth factor
Generic name given to various growth factors isolated from several ocular tissues. Specific factors that have been identified are two heparin binding growth factors designated EDGF-1 and EDGF-2.
See also: RDGF (retina-derived growth factor) (see also: HBGF [heparin binding growth factors]).
See REFERENCES for entry EDGF.
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