gas-2 |
GAS2L2 |
multiple myeloma cells |
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[Growth arrest-specific gene-2-like-1] The gene encoding this protein has been cloned by Zucman-Rossi et al (1996), who referred to it as GAR22 [GAS2-related protein on chromosome 22]. The protein is most related to gas-2 (see also: gas genes) and
Goriounov D et al (2003) have identified two splice isoforms. GAR22-beta protein expression is induced by growth arrest, but GAR22-alpha is not detected. GAR22-alpha isoform binds preassembled microfilaments but does not bind microtubules, wheras GAR22-beta binds both microfilaments and microtubules.
Role as tumor suppressor
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