H-chain-binding protein |
HCII |
GC-1 |
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[human collagenase inhibitor] HCI has been identified as a secretory product of platelets and alveolar macrophages. It plays a major role in modulating the activity of interstitial collagenase and a number of connective tissue metalloendoproteases.
HCI is identical with TIMP (tissue inhibitor of metalloproteinases), which has been renamed TIMP-1, following identification of other related inhibitors (Carmichael et al, 1986).
For other proteins (or fragments thereof) with at least one additional activity that differs from the established 'classical' activity of the parent protein see also: Dual identity proteins and Cryptides MiniCOPE Dictionary.
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