COPE Advertising options


COPE Homepage Bottom of page Previous entry:
Next entry:
Random entry:
Search COPE:

Please donate

If COPE helps you,
please help me to continue my work.
Make a donation you can afford.


This type 1 interferon protein is co-expressed with IFN-gamma by the trophectoderm of the pig conceptus between day 12 and day 18 of gestation (Lefevre et al, 1998). Pig IFN-delta is a protein 149 amino acids. The protein shows high antiviral activity on porcine cells and is inactive on human cells. IFN-delta has high antiproliferative activity, which is enhanced significantly in the presence of IFN-gamma. On pig cells IFN-delta binds to the same type I receptor as IFN-alpha.

The vaccinia virus encoded factor B18R has been shown to neutralize the antiviral activity of porcine IFN-delta with high efficiency (Vancova et al, 1998).

Cochet et al (2009) have reported that IFN-delta is not restricted topigs and is more widely represented among mammals. Ovine IFN-delta (139 amino acids) appears to be the shortest natural type 1 interferon protein presently known. Two IFN-delta proteins, named IFN-delta-1 and IFN-delta-2 have been found in the horse. They are thought to play an important role in maternal-fetal interactions during early pregnancy in the horse. Cochet et al (2009) have identified also potentially functional IFN-delta genes from various species belonging to the four mammalian lineages Afrotheria, Xenarthra, Euarchontoglires and Laurasiatheria). These interferons show a high rate of identity with porcine IFN-delta.

Copyright 2012 by H IBELGAUFTS. All rights reserved.


See REFERENCES for entry IFN-delta.

Click BACKLINKS to see which COPE entries contain the term IFN-delta .

COPE Homepage Top of Page

SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials
# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Please inquire. COPE is interested in contacts with corporate sponsors appreciating and committed to communication biology

              Created, developed, and maintained by Prof Dr H Ibelgaufts              
About the author of COPE
  |    Contact COPE   |    Terms & Conditions

U L T R A   P O S S E   N E M O   O B L I G A T U R