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IFN-omega

[Omega-Interferon] IFN-omega is a natural component of human leukocyte interferon (see also: LeIFN). This type 1 interferon protein is called also IFN-alpha II1. It displays a high degree of homology with various IFN-alpha species including positions of the cysteine residues involved in disulfide bonds. However, sequence divergence allows classification as a unique protein family. A related protein is bovine trophoblast protein TP-1.

IFN-omega binds to the same receptors as IFN-alpha and IFN-beta. To date the exact biological activities and the physiological role of this interferon are unknown. The protein has been shown to possess antitumor effects for human tumor xenografts in nude mice.

Mire-Sluis et al (1996) have described bioassays for IFN-alpha, IFN-beta and IFN-omega that exploit the ability of these factors to inhibit proliferation of TF-1 cells induced by GM-CSF. The bioassays can be used also with Epo and TF-1 cells, or Epo and Epo-transfected UT-7 cells.


Copyright 2012 by H IBELGAUFTS. All rights reserved.
ENTRY LAST MODIFIED: January 2002



 

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