IRAK3 |
IRAKM |
embryonic stem cell-associated transcript 9 |
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[IL1 receptor-associated kinase-4] The gene is known also as REN-64 (NY-REN-64), an antigen identified in a renal tumor (Scanlan et al, 1999). IRAK4 (Li et al, 2002) is a mediator of signaling through the IL1 receptor and TLR (Toll-like receptors). The protein has an N-terminal death domain and a central kinase domain. It interacts weakly with IRAK1, MyD88, and TRAF6. IRAK4 lacking the kinase domain inhibits activation of NF-kappa-B and IRAK1 by IL1, but not by TNF-alpha
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