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NF-kappa-B

[Nuclear factor kappa-B] NF-kappa-B is a transcription factor identified originally in nuclei of mature B-cells as a protein essential for kappa immunoglobulin light chain gene expression. Expression of NF-kappa-B is not restricted to B-cells (Sen and Baltimore, 1986). NF-kappa-B is a pleiotropic transcription factor expressed in numerous different cell types after stimulation and/or cell activation by a wide variety of stimuli (cytokines, growth factors and mitogens, hormones, receptor ligation, crosslinking of surface molecules, viruses and viral proteins, oxidative stress, and chemical agents such as phorbol esters ... ... ... ... ... Subscribe to continue reading! ... ...

 

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