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LCI

[Leydig cell inhibitor] A factor of 21 kDa purified from the culture medium of seminiferous tubules prepared from adult rats that inhibits hCG-stimulated testosterone production by purified Leydig cells (Zwain and Cheng, 1994). LCI also inhibits hCG-stimulated cAMP production by Leydig cells and the forskolin- and cholera toxin-stimulated testosterone and cAMP production but has no apparent effect on the binding of hCG to Luteinizing hormone receptors.

LCI also inhibits the conversion of exogenously added 22R-hydroxycholesterol, pregnenolone, progesterone, and 17 alpha-hydroxyprogesterone to testosterone. It has no effect on the conversion of dehydroepiandrostenedione and androstenedione to testosterone. LCI is distinct from other known potent Leydig cells inhibitors such as IL1 and TGF-beta.


LAST MODIFIED: September 2003

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LCI

The following COPE entries contain this entry term or one of its hypertext synonyms:

Leydig cell inhibitor, Leydig cells.

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