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[Macrophage-derived Apoptosis-Inducing RBCC protein] This RING-B-Box-coiled-coil (RBCC) protein consists of an N-terminal RING finger, followed by a B-Box zinc finger, a coiled-coil domain and a B30.2 domain. MAIR mRNA is expressed widely in mouse tissues. Its expression is induced by M-CSF in murine peritoneal and bone marrow macrophages. Ectopic expression of MAIR causes activation of caspase-7, caspase-8 and caspase-9 but not caspase-3, followed by apoptosis.

The cDNA has been cloned as KIAA1098. The gene has been identified independently as HLS5 [hemopoietic lineage switch 5]. The approved gene symbol is TRIM35 [tripartite motif-containing protein 35].

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.

Copyright 2012 by H IBELGAUFTS. All rights reserved.


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