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MCGEF

[mast cell growth-enhancing factor] This factor is found in the conditioned medium of KCMH-1 cells, a cell line established from keratinocytes of a chemically induced skin tumor, transplantation of which into the skin of mice results in accumulation of mast cells around the developing tumor tissue. The factor enhances the growth of mast cells in vitro when they are cultured in the presence of NIH 3T3 fibroblasts. The factor has been found to be identical with LIF (leukemia inhibitory factor). Recombinant LIF shows MCGEF activity. MCGEF activity is neutralized completely by an anti-LIF monoclonal antibody (Tanaka et al, 2001).

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