MGC1 |
MGC-24v |
GIGRKFLGGVKTTFRCGVKDFASKHLYamide |
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[multiglycosylated core protein-24] MGC-24 has been identified as a 24 kDa glycoprotein binding to peanut agglutinin (Masuzawa et al, 1992). The protein is rich in hydroxyl amino acids and cysteine, and lacks repeating motifs. MGC-24 mRNA is intensely expressed in normal tissues of the colon, small intestine and thyroid, and in some nude mouse-transplanted colorectal and pancreatic adenocarcinomas. Matsui et al (2000) have reported that lower MGC-24 mRNA levels in colon carcinomas and in the adjacent normal mucosa epithelium correlate with lymphatic vessel invasion by the carcinoma. Higher ratios of the soluble form to the transmembrane form are correlated with less venous invasion and less remote metastasis.
The protein is the mouse ortholog of rat endolyn
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