Mgrp |
MGSA-alpha |
Kaposi sarcoma-associated herpesvirus orf63 |
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[melanoma growth stimulatory activity] Human MGSA (73 amino acids) is encoded by a gene mapping to chromosome 4q21. This gene is called GRO (growth regulated oncogene; see also: Oncogene) and contains four exons. The GRO gene was identified initially by its constitutive overexpression in spontaneously transformed Chinese hamster fibroblasts.
Three different GRO genes have been described. At the nucleotide level they show a homology of approximately 90 %. GRO-alpha encodes MGSA (also termed MGSA-alpha). Several variants are known (see also: FINAP,
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