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MMP-3

[matrix metalloproteinase-3] This proteinase is known also as stromelysin-1 (abbr. STMY1, STR1, SL-1), transin (transin-1), collagenase activating protein, procollagenase activator, proteoglycanase.

MMP-3 is produced as an inactive proform that requires proteolytic cleavage for activation. Moilanen et al (2003) have reported that trypsin-2 can directly activate MMP-3. Wilhelm et al (1992) have reported that the carboxyl-terminal hemopexin domain of the metalloproteinase MMP-3 has no known function and can be removed without a loss of enzymatic activity.

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