M retinal ganglion cells |
MRG |
unc-5 homolog 3 |
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[microglial response factor-1] The gene encoding this factor was isolated from rat cerebellar granule neurons degenerating and dying from cell death by apoptosis in vitro. The expression of MRF-1 is upregulated during the degeneration process. MRF-1 is expressed in microglial cells, monocytes, and perivascular cells. The gene encodes a protein of 177 amino acids with a single EF-hand calcium-binding motif. The factor is identical with AIF-1 (allograft inflammatory factor-1).
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