megalocytes |
MEG-CSA |
TRAP-1-like protein |
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This biochemically uncharacterized factor of 31.2 kDa was discovered in a model of thrombocytopenia in sheep (Kuter et al, 1994). Megapoietin stimulates an increase in the number and ploidy of megakaryocytes in bone marrow cultures. Injection of the partially purified factor into rats leads to a 24 % increase in the numbers of megakaryocytes, a 60 % increase in mean ploidy, and a 77 % increase in counts of platelets. It appears that Megapoietin is identical with Thrombopoietin (Kuter, 1996).
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