MetAP2

[Methionine aminopeptidase-2, methionyl aminopeptidase-2] In the nomenclature of enzymes MetAP2 has been given the designation EC3.4.11.18. In some older publications and in databanks the enzyme is being referred to as Peptidase M.

This enzyme catalyzes the preferential release of methionine from the N-terminus of nascent proteins (Li and Chang, 1996). The enzyme also protects the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation (Wu et al, 1993). Datta et al (2004) have reported that treatment of cells with fumagillin increases the stability of MetAP2 and reduces phosphorylation of extracellular signal-regulated kinases.

Li and Chang (1995) have ... ... ... ...
 
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Entry last modified: June 2009