NijA |
Nil-2-a |
Lectin-like immunoreceptor |
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[NF-kappa-B-inducing kinase] This serine/threonine kinase is known also as MAP3K14 (mitogen-activated protein kinase kinase kinase-14). The NIK cDNA encodes a protein of 947 amino acids (Malinin et al, 1997). It is involved in the activation of transcription factor NF-kappa-B in response to TNF-alpha, IL1, and FAS antigen. NIK binds to the signal transducer TRAF2.
Yin et al (2001) have generated knock-out mice lacking expression of NIK. Mutant mice lack lymph nodes and an abnormal spleen and thymus architecture. Antibody responses upon immunization are diminished. An analysis of fibroblasts
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