NRK-49F |
nrln1 |
Hrs-binding protein |
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[neu-related lipocalin] This protein has been identified by Stoesz and Gould (1995) as a protein that is overexpressed in mammary carcinomas initiated by overexpression of the neu oncogene but not in tumors induced by weaker tumor-initiating agents, including activated ras oncogene and the chemical carcinogens dimethylbenz[a]anthracene and N-nitroso-N-methylurea. The protein is identical with Lipocalin-2 (Stoesz et al, 1998). Unlike the expression patterns in murine mammary carcinomas, human breast cancers show a heterogenous expression of this gene and expression does not correlate with levels of neu oncogene expression. There appears to be a significant correlation between Lipocalin-2
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