PRLR |
PRM |
Glycine dehydrogenase |
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[PDGF-receptor beta-like tumor suppressor] PRLTS encodes a protein of 375 amino acids with significant sequence similarity to the extracellular ligand-binding domain of the beta receptor of PDGF. The approved gene symbol is PDGFRL [PDGF receptor-like].
The gene was isolated as a candidate tumor suppressor gene (see also: Oncogene) from a 600 kb region on chromosome 8p21.3-p22 (Fujiwara et al, 1995). It is commonly deleted in sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. Structural gene rearrangements were found in a sporadic non-small cell lung cancer. Somatic missense and frame-shift mutations were found in two sporadic hepatocellular carcinomas and one colorectal cancer.
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