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PUMA

[p53 upregulated modulator of apoptosis] The expression of this gene is upregulated soon after expression of the p53 tumor-suppressor protein and is restricted to mitochondria (Nakano and Vousden, 2001). PUMA is the same as BBC3 (the approved gene symbol). A databank synonym is JFY1.

The protein is one of the BH3-only proteins with a single BH3 domain and no other BCL2 homology domains. Alternative splicing gives rise to two proteins, PUMA-alpha (193 amino acids), and PUMA-beta (131 amino acids), which both display similar activities with respect to being able to induce apoptosis.

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