BBC3

[BCL2 binding component 3] The protein is one of the BH3-only proteins with a single BH3 domain and no other BCL2 homology domains. BBC3 is the approved gene symbol for PUMA [p53 upregulated modulator of apoptosis]. A databank synonym is JFY1.

BBC3 is a strong promoter of cell death by apoptosis. Its expression increases in response to exposure to DNA-damaging agents and expression of the tumor suppressor gene p53, which mediates DNA damage induced apoptosis. Expression of BBC3 is induced also by treatment of thymocytes with dexamethasone, and ... ... ... ...
 
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Entry last modified: March 2002