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Perinerin

This antimicrobial peptide has been purified from the marine clamworm Perinereis aibuhitensis Grube (Pan et al, 2004). Perinerin is a highly basic and hydrophobic protein of 51 amino acids (FNKLKQGSSKRTCAKCFRKIMPSVHELDERRRGANRWAAGFRKCVSSICRY). It shows marked activity in vitro against both Gram-negative bacteria and Gram-positive bacteria and fungi. Perinerin appears to be expressed constitutively.

For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also: Innate immunity and defense peptides Dictionary.

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Entry last modified: November 2006

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