prolipoblasts |
prolyl 3-hydroxylase 1 |
Gal-3BP |
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Prolixicin (11 kDa) is an antimicrobial peptide isolated from the hemipteran insect, Rhodnius prolixus (Ursic-Bedoya, 2011). Prolixicin is produced by both adult fat body and midgut tissues in response to bacterial infection of the hemolymph or the midgut. Unlike most insect antibacterial peptides, the prolixicin gene does not seem to be regulated by NF-kappa-B binding sites, but its promoter region contains several GATA sites. Recombinant prolixicin has strong activity against the Gram-negative bacterium Escherichia coli and differential activity against several Gram-negative bacteria and Gram-positive bacteria. The peptide shows no significant toxicity against Trypanosoma cruzi, the human parasite transmitted by R. prolixus.
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