promegaloblasts |
Promegapoietin-1 |
nursing cells |
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abbr. PMP. PMP-1 (promegapoietin-1) and PMP-1a (promegapoietin-1a) are chimeric dual agonist of the cellular MPL gene, the receptor for thrombopoietin, and the human IL3 receptor (see also Muteins) (Doshi et al, 2001). They function as multilineage hematopoietic growth factors that can simultaneously activate signaling pathways induced by IL3 and thrombopoietin.
Both proteins are potent stimulators of hematopoiesis in myelosuppressed nonhuman primates and can effectively alleviate acute radiation syndrome in animals (Farese et al, 2001).
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