Muteins

[mutant proteins] A general term describing mutated recombinant proteins. These proteins usually carry single or multiple amino acid substitutions. These proteins are derived frequently from cloned genes that have been subjected to site-directed or random mutagenesis, or from completely synthetic genes.

High-resolution mutational and structural analyses have revealed a great deal about the molecular basis for the actions of cytokines. From these studies it has been possible to engineer homologs of cytokines with altered biological properties. Cytokines with greater specific activity in cell proliferation assays (see: bioassays ... ... ... ...
 
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Entry last modified: March 2003