REPELL-microglia

REPELL is an acronym from repetitive low-dose LPS. This term pertains to a distinct subpopulation of microglial cells emerging after repetitive stimulation with low doses of bacterial lipopolysaccharides (Mizobuchi et al, 2020). REPELL-microglia are characterised by high phagocytosis activity and a high expression of pro-inflammatory mediators (Nitric oxide synthase 2, CCL1, IL12B, and CD86), anti-inflammatory mediators (IL10, ARG1 [arginase-1], IL13 receptor IL13RA2, and MRC1 [mannose receptor C type-1] (CD206)), as well as neuroprotective mediators ( ... ... ... ...
 
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Entry last modified: November 2020