SAO
[Southeast Asia ovalocytosis] This blood group antigen occurs commonly in Southeast Asia and the Western Pacific. It is defined by a deletion of 9 amino acids (residues 400-408) in erythrocyte band 3 protein (Jarolim et al, 1991; Schofield et al, 1992). The mutated protein retains its normal secondary structure (Sarabia et al, 1993; Moriyama et al, 1992), but the membrane domain is disordered (Moriyama et al, 1992; Cheung and Reithmeier, 2005), and the protein does not carry out anion transport (Schofield et al, 1992).
SAO is a hematological condition in which erythrocytes are ovalocytes that are more rigid than normal (Mohandas et al, 1984; Eng LI
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