Cytokines & Cells Online Pathfinder Encyclopaedia
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Horst Ibelgaufts' COPE:
Cytokines & Cells Online Pathfinder Encyclopaedia |
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This term has been used in several different ways.
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(-1-) suppressor E receptor factor
see: Suppressor factors.
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(-2-) suppressive E receptor
This factor was identified in the malignant effusions derived from ovarian, lung or head and neck cancer patients. It inhibits T-cell dependent immune responses in vivo and in vitro, including the inhibition of E-rosetting and may be a negative feed-back regulator of immune response produced by activated macrophages. Amino acid sequences of the two polymeric components of SER are identical with the beta and alpha 2 subunits of normal adult Haptoglobin. Tumor-associated SER is 100-1000 times more potent an immunosuppressor than normal plasma haptoglobin and is immunochemically analogous to the neonatal form.
REFERENCES: Oh SK et al An analogy between fetal haptoglobin and a potent immunosuppressant in cancer. Cancer Research 47: 5120-5126 (1987); Oh SK et al Monoclonal antibody to SER immune suppressor detects polymeric forms of haptoglobin. Hybridoma 8: 449-466 (1989); Oh SK et al Interference with immune response at the level of generating effector cells by tumor-associated haptoglobin. Journal of the National Cancer Institute 82: 934-940 (1990); Oh SK et al Quantitative differentiation of the haptoglobin-related gene product from haptoglobin in human plasma: a possible test for tumor-associated antigen. Hybridoma 11: 1-12 (1992)
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(-3-) sheep erythrocyte receptor
see: The sheep erythrocyte receptor is identical with CD169. The designation erythrocyte receptor may refer also to CD2.
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