Sma and Mad related proteins |
SMAC-beta |
Trim30-alpha |
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[second mitochondria-derived activator of caspase] This protein (239 amino acids) has been purified by Du et al (2000). The murine counterpart has been isolated by Verhagen et al (2000), who called it DIABLO (direct IAP-binding protein with low pI). DIABLO is the approved gene symbol. SMAC is expressed widely; highest levels are found in adult testis, heart, liver, kidney, spleen, prostate, and ovary.
SMAC/DIABLO is a mitochondrial protein. It is released together with cytochrome C during cell death by apoptosis and promotes cytochrome C-dependent caspase activation by neutralizing apoptosis-inhibitory proteins (IAP) (see also: mitochondrial apoptosis).
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