Somatomedins

Collective term for a family of peptides found in human plasma that stimulate cartilage growth by inducing the synthesis of collagen and other proteins (Daughaday, 1972).

Somatomedin A is a mixture of IGF-1 and IGF-2 (Enberg et al, 1984). Rat basic somatomedin has been shown to be IGF-1 (Rubin et al, 1982).

A sequence contained within the N-terminal region of vitronectin has been termed Somatomedin B.

Somatomedin C, the major member of this group of proteins, is identical with IGF-1 (Klapper et al, 1983; Hintz and Rinderknecht, 1980). See also: ... ... ... ...
 
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