STAP cells |
staphylococcal complement inhibitor |
sex cells |
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Staphylocoagulase, encoded by the coa gene, is one of the extracellular virulence factors mediating immune response evasion. It is produced by Staphylococcus aureus strains, and is regarded as a marker for discriminating Staphylococcus aureus from other less pathogenetic staphylococci called as coagulase-negative staphylococci. Watanabe et al (2009) have reported the nucleotide sequences of 105 Staphylocoagulase genes.
Staphylocoagulase causes the coagulation of plasma without the usual proteolytic cleavages caused by complement factor Xa. Staphylocoagulase binds to the proform of thrombin and the complex of Staphylocoagulase and prothrombin induces plasma coagulation by converting fibrinogen into fibrin (Hemker et al, 1975; Kawabata et al, 1986).
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