Staphylococcus aureus scn |
staphylolysin |
PRR1 |
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[von Willebrand factor-binding protein] This protein is encoded by the Staphylococcus aureus vwb gene. vWbp (482 amino acids) has been identified by Bjerketorp J et al (2002). The interaction between vWbp and von Willebrand factor is very specific and is mediated by a region of 26 amino acids in the C-terminal part of von Willebrand factor. The protein may enable the pathogen to adhere to surfaces coated with von Willebrand factor.
Bjerketorp J et al (2004) have shown that vWbp coagulates human and porcine plasma efficiently, but is less active against plasma from other species. Species-specific coagulation by vWbp depends on the interaction with prothrombin
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