TFRC

[transferrin receptor, transferrin receptor 1] In the nomenclature of CD antigens this protein, which is one of the receptors for transferrin, has been given the designation CD71. Other designations: TRFR, TFR, TFR1.

TFRC is usually absent or expressed at low levels on non-proliferating cells but is rapidly upregulated upon cell activation and proliferation of normal or neoplastic cells (for overview see: Ponka and Lok, 1999; Richardson and Ponka, 1997). The TFRC receptor is important for cellular iron uptake and iron homeostasis and binds holotransferrin, which is obtained from circulating ... ... ... ...
 
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Entry last modified: May 2021