TIG2 |
Tiger frog virus CARD-like caspase |
JAK binding protein |
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[TP53-induced glycolysis and apoptosis regulator] TIGAR has been identified as a p53-inducible gene by Bensaad et al (2006). The approved gene symbol is C12orf5 [chromosome 12 open reading frame 5].
TIGAR expression lowers fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species levels. This correlates with an ability of TIGAR to protect cells from cell death by apoptosis apoptosis associated with reactive oxygen species. Knock-down of endogenous TIGAR expression sensitizes cells to p53-induced cell death
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