TNF-BF

[tumor necrosis factor blocking factor] This factor of 28 kDa is isolated from serum ultrafiltrates of tumor patients. It is obtained by processing of the aminoterminal end of the extracellular domain of the TNF-alpha membrane receptor. A similar factor is known as TNF binding protein (TNFBP-1). It is a soluble 60 kDa fragment of the extracellular TNF-alpha receptor domain.

TNFBP-1 is detected in serum, urine, and cell conditioned medium of several human tumor cell lines. Serum TNFBP-1 ... ... ... ...
 
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Entry last modified: September 1993