Tpex cells |
TPFKLSLHamide |
transmembrane metalloproteinase-like, disintegrin-like, cysteine-rich 2 |
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[thymocyte proliferation factor] This factor was found initially in the conditioned medium of cultured human mixed peripheral blood leukocytes. It is identical with LAF (lymphocyte activating factor) and HP1 (helper peak 1) and hence identical with IL1.
Another factor with TPF activity is released by human monocytes and macrophages treated with fibrogenic silica dust. It also causes cell activation of fibroblasts as measured by an increase in the proliferation of fibroblasts. The factor is most likely identical with IL1.
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