TRADD

[TNFR1-associated death domain protein] This protein of 34 kDa has been found to associate with the cytoplasmic segment of the type 1 TNF receptor (TNFR1). Mouse TRADD shares 75 % overall amino acid sequence identity with human TRADD (Pan et al, 1995).

TRADD contains a novel death domain that allows self-association of TRADD and binding to the death domain in the cytoplasmic segment of TNFR1. This can mediate the activation of the transcription factor NF-kappa-B and induction of apoptosis. TRADD, identified by Hsu et al (1995), specifically interacts with an intracellular domain of TNFR1 known to be essential for mediating ... ... ... ...
 
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Entry last modified: 30/12/1998