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TRADD

[TNFR1-associated death domain protein] This protein of 34 kDa has been found to associate with the cytoplasmic segment of the type 1 TNF receptor (TNFR1). Mouse TRADD shares 75 % overall amino acid sequence identity with human TRADD (Pan et al, 1995).

TRADD contains a novel death domain that allows self-association of TRADD and binding to the death domain in the cytoplasmic segment of TNFR1. This can mediate the activation of the transcription factor NF-kappa-B and induction of apoptosis. TRADD, identified by Hsu et al (1995), specifically interacts with an intracellular domain of TNFR1 known to be essential for mediating ... ... ... ... ... Subscribe to continue reading! ... ...

 

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